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Epstein Barr Virus Nuclear Antigen (EBNA) IgM ELISA kit

NR-R10041

$840.00

More info

Principle
Indirect ELSIA, Antigen coated plate
 
Detection Range
Qualitative Positive; Negative and Cut off
 
Size
96T
 
Specificity                      94%

Sensitivity                      99%
 
Assay time
~ 100 min
 
Shelf Life
12~14 Months from the Manufacturing Date
 
Storage
Store at 2 - 8ºC. 
 
Sample volume
10 µL Serum or Plasma
 
Detection Method
Chromogenic
  
Kit Components
 
 
 
1. Low Positive Control: 1vial 
 
 
2. One 96-well plate precoated with recombinant antigen
 
 
3. Assa diluent buffer: 2 vials
 
 
4. HRP conjugated: 1 vial
 
 
5. High Positive Control: 1 vial
 
 
6. Negative Control:1vial
 
 
7. Calibrator: 1 vial
 
 
8. TMB substrate: 1 vial
 
 
9. TMB stop solution: 12 ml.

 

Background

 

Epstein-Barr nuclear antigen 1 (EBNA1) is a multifunctional, dimeric viral protein associated with Epstein-Barr virus (EBV). It is the only EBV protein found in all EBV-related malignancies. It is important in establishing and maintaining the altered state that cells take when infected with EBV. EBNA1 is the only identified latent protein-encoding genes that it consistently expressed in Burkitt’s lymphoma cells. EBNA1 may regulate cellular genes during EBV’s latency phase and thus regulate EBV associated tumors. Some studies suggest that it is possible that EBNA1 may be involved in the maintenance function in tumors. Transgenic mice expressing EBNA1 in B cell lines showed a predisposition to B cell lymphoma, thus demonstrating that EBNA1 is a viral oncogene and that it likely plays a role in B cell neoplasia. 

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