C1 is a non-covalent complex of three different proteins (C1q, C1r and C1s) bound together in a calcium-dependent complex.C1 binds and is activated by antibodies bound to antigens yielding a protease that initiates the classical pathway of complement.
-70â„ƒ or below. Avoid freeze/thaw.
Normal human serum
Purified C1 complex is free of other complement proteins, but it contains other high MW plasma proteins.
>0.20 mg C1/mL based on functional activity measurement
0.5 to 5.0 mg/mL total protein
more than 250,000 C1H50 units/mg total protein.
10 mM EDTA, 300 mM NaCl, 40% glycerol, pH 5.5, 50 mM sodium acetate, 50 mM EACA, 10 mM benzamidine.
None, 0.22 µm filtered.
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