C1r enzyme is the activated form of C1r proenzyme. C1r is a subunit of the C1 complex which is the first complement component in the classical pathway of complement. C1r proenzyme is an inactive zymogen until C1 is activated. C1r is activated when C1 is activated by antibodies bound to antigens yielding C1r enzyme, the first protease that initiates the cascade.
-70â„ƒ or below. Avoid freeze/thaw
Normal human serum
>90 % C1r will bind with excess C1-INH
>90 % by SDS PAGE
92,000 Da (2 chains)
10 mM Imidazole, 140 mM NaCl, 2 mM EDTA, pH 7.4
None, 0.22 µm filtered
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