The protease inhibitor C1-INH prevents the spontaneous activation of complement and limits consumption of C2 and C4 by rapidly inactivating C1r, C1s and MASP2. It is the only plasma serine protease inhibitor (Serpin) capable of interacting with and inhibiting activated C1.
-70â„ƒ or below. Avoid freeze/thaw.
Normal human serum
>95 % by SDS PAGE
110,000 Da (single chain)
>90 % active protein
10 mM sodium phosphate, 145 mM NaCl, pH 7.3
None, 0.22 µm filtered.
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