Human C8 Protein

Background:

Native human C8 is a naturally glycosylated protein composed of three polypeptide chains. The alpha chain (64,000 Da) and the gamma chain (22,000 Da) are disulfide linked. The beta chain (64,000 Da) is non-covalently bound to the a-g complex. C8 is essential for formation of the membrane attack complex (MAC) and is activated non-proteolytically by binding to newly-formed C5b, C6, C7 complexes on the cell membrane.

Storage:

-70℃ or below. Avoid freeze/thaw

Source:

Normal human serum

Activity:

Purity:

>90% versus normal human serum standard        

>90% by SDS-PAGE

Molecular Weight:

Size:

151,000 Da (3 chains)

250 µg/vial

Concentration:

1.0 mg/mL

Buffer:

10 mM sodium phosphate, 145 mM NaCl, pH 7.3

Preservative:

None, 0.22 µm filtered