Human Complement Factor Ba (fragment of factor B)

Background:

In the presence of Mg⁺⁺ , factor B binds to C3b and the C3b,B complex can be activated by factor D, a serine protease that circulates as an active trypsin-like serine protease. Cleavage of factor B by factor D causes the release of the Ba fragment (33,000 Da) and leaves the 60,000 Bb fragment bound to C3b. This Ba fragment comes from the N-terminal of factor B and it contains three CCP domains which interact with C3b.

Storage:

-70 C or below. Avoid freeze/thaw

Source:

Normal human serum

Purity:

>95% by SDS-PAGE

Molecular Weight:

Size:

33,000 Da (single chain)

100 µg/vial

Concentration:

1.0 mg/mL

Buffer:

Phosphate-buffered saline, pH 7.3

Preservative:

None, 0.22 µm filtered