Human Complement Factor Bb (fragment of factor B)

Background:

Cleavage of factor B by factor D causes the release of the Ba fragment and leaves the Bb fragment bound to C3b. This Bb subunit comes from the C-terminal of factor B and it contains the proteolytic active site of the serine protease C3b,Bb. C3b,Bb is called a C3 and a C5 convertase, because it converts both of these proteins to their active forms by cleaving off the small peptides C3a and C5a, respectively.

Storage:

-70 C or below. Avoid freeze/thaw

Source:

Normal human serum

Purity:

>90% by SDS-PAGE

Molecular Weight:

Size:

60,000 Da (single chain)

250 µg/vial

Concentration:

1.0 mg/mL

Buffer:

Phosphate-buffered saline, pH 7.3

Preservative:

None, 0.22 µm filtered