Prothrombin Complex ( PCC )

Prothrombin Complex ( PCC )

DescriptionProthrombin complex is a double virus-inactivated concentrate, containing equal concentrations of Factors II, VIII, IX, X and Heparin.SourceEscherichia Coli.Physical AppearanceSterile Filtered White lyophilized (freeze-dried)
Lyophilized Powder from 0.1M sodium chloride and 10mM sodium citrate buffer.
It is recommended to reconstitute the lyophilized Prothrombin Complex in sterile 18M-cm H2O.
Prothrombin complex is a double virusinactivated concentrate, containing equal concentrations of Factors II, VIII, IX, X and Heparin.
Protein Background
Prothrombin Complex Concentrate (PCC) is a combination of several blood clotting factors II, VII, IX and X. PCC is used in the treatment of the congenital bleeding disorders associated with Factors II, VII, IX, and X deficiencies. PCC reverses the effect of warfarin (a coumarin anti-coagulant) and is used in cases of significant bleeding in patients with a coagulopathy, for example, gastrointestinal haemorrhage or intracranial haemorrhage. The PCC is also extensively used in treating acquired coagulation abnormalities secondary to vitamin K deficiency, warfarin ingestion, and various types of liver disease. Hepatitis, anaphylaxis and thrombosis have been reported as complications of prothrombin complex concentrates administration.
PCC, Prothrombin Complex.
Reagent Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Lyophilized Prothrombin-Complex although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Prothrombin-Complex should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.


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