FAK ( 4A9D ) Antibody

Host/Type

Mouse Monoclonal

Unit

0.1 ml

Isotype

Applications

Species reactivity

Format

Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.

Description

FAK (Focal adhesion kinase) is a 1074 -amino acid protein (~118 kDa). It is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. FAK is concentrated at the basal edge of only basal keratinocytes that are actively migrating and rapidly proliferating in repairing burn wounds, activated and localized to the focal adhesions of spreading keratinocytes in culture. Thus, it has been postulated that FAK may have an important in vivo role in the re-epithelialization of human wounds. FAK protein tyrosine kinase activity has also been shown to increase in cells stimulated to grow by use of mitogenic neuropeptides or neurotransmitters acting through G protein-coupled receptors.

Alternate Names

Focal adhesion kinase 1; FADK 1; Focal adhesion kinase-related nonkinase; FRNK; Protein phosphatase 1 regulatory subunit 71; PPP1R71; Protein-tyrosine kinase 2; p125FAK; pp125FAK FAK; FAK1; PTK2

Accession No.

Q05397

Clonality

4A9D6

Antigen

Purified recombinant fragment of FAK expressed in E. coli.

Application Notes

WB: 1:500-1:2000

Storage

Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.