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Transforming Growth Factor-Beta 3 Human Recombinant ( TGF b 3 Human )

DescriptionTGF-b3 Human Recombinant produced in E.Coli is a disulfide-linked homodimeric, non-glycosylated, polypeptide chain containing 112 amino acids and having a molecular mass of 25,445 Dalton. The TGF-b 3 is purified by standard chromatographic

$193.00

Data sheet

Formulation The protein solution contains 20% Ethanol and 0.12% Acetic acid.
Purity Greater than 96.0% as determined by SDS-PAGE.
Description TGF-beta 3 Human Recombinant produced in E.Coli is a disulfide-linked homodimeric, non-glycosylated, polypeptide chain containing two 112 amino acid chains and having a total molecular mass of 25.5kDa. The TGF-b 3 is purified by standard chromatographic techniques.
Protein Background Transforming growth factor betas (TGF Betas) mediate many cell-cell interactions that occur during embryonic development. Three TGF Betas have been identified in mammals. TGF Beta 1, TGF Beta 2 and TGF Beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule.
Expression host Escherichia Coli.
Synonyms Transforming Growth Factor-beta3, TGFB3, ARVD, FLJ16571, TGF-beta3.
Reagent Appearance Sterile Filtered clear solution.
Stability TGF-beta 3 although stable at room temperature for 1 week, should be stored at 4°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Amino acid sequence ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS.
Biological Activity The activity is determined by the ability to induce chondrogenic differentiation.
References 1.Title: Altering the Architecture of Tissue Engineered Hypertrophic Cartilaginous Grafts Facilitates Vascularisation and Accelerates MineralisationPublication: DOI: 10.1371/journal.pone.0090716, March 04, 2014Link: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.00907162. Title: Oxygen tension differentially regulates the functional properties of cartilaginous tissues engineered from infrapatellar fat pad derived MSCs and articular chondrocytesPublication: Osteoarthritis and Cartilage 18.10 (2010): 1345-1354.Link: http://www.sciencedirect.com/science/article/pii/S1063458410002293

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