dCas9 (D10A & H840A)

dCas9 (D10A & H840A)

dCas9 (D10A & H840A)

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The functions of CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and CRISPR-associated (Cas) genes are essential in adaptive immunity in select bacteria and archaea. CRISPR uses a Cas9 protein to recognize DNA sequences, with target specificity solely determined by a small guide (sg) RNA and a protospacer adjacent motif (PAM) Upon binding to target DNA, the Cas9-sgRNA complex generates a DNA double-stranded break. Based on this RNA- guided nuclease activity, CRISPR has been showed to be a powerful tool in editing the genomes of a broad range of organisms. Furthermore, a repurposed, nuclease-deactivated Cas9 (dCas9) protein has been used to regulate endogenous gene expression and labeling of genomic loci in living and fixed cells.
E. coli
Recombinant dCas9 (D10A & H840A) protein is suitable for use in imaging of genomic oci in living cells and fixed cells as well as for gene expression regulation.
Recombinant dCas9 (D10A & H840A) protein in solution is temperature sensitive and must been stored at -20°C or below to prevent degradation. Avoid repeated freeze /thaw cycles and keep on ice when not in storage. Stable for 1 year from the date of shipping when stored and handled properly.
1 μg/μl

For Research Use Only
dCas9 (D10A & H840A)


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