Vascular Cell Adhesion Molecule 1 Human Recombinant ( VCAM1 Human )

Vascular Cell Adhesion Molecule 1 Human Recombinant ( VCAM1 Human )
$175.00

DescriptionVCAM1 Human Recombinant is expressed in E. coli containing 674 amino acids (a.a. 25-698) fused to an amino terminal hexahistidine tag, having a total MW of 78.8kDa.SourceEscherichia Coli.FormulationVCAM1 is supplied in 10mM Tris-HCl (pH
Formulation
VCAM1 is supplied in 10mM Tris-HCl (pH 8), 250mM NaCl, 0.5mM DTT, 1.5mM Cysteine, and 50% Glycerol.
Purity
Greater than 95% as determined by SDS-PAGE.
Description
VCAM1 Human Recombinant is expressed in E. coli containing 674 amino acids (a.a. 25-698) fused to an amino terminal hexahistidine tag, having a total MW of 78.8kDa.
Protein Background
VCAM1 is a member of the Ig superfamily. It is a cell surface sialoglycoprotein expressed by cytokine activated endothelium. VCAM-1 contains 6 or 7 immunoglobulin domains, and is expressed on both large and small vessels only after the endothelial cells are stimulated by cytokines. The protein has a number of functions including the regulation of leukocyte migration, leukocyte endothelial cell adhesion and signal transduction and may play a role in a number of inflammatory diseases (artherosclerosis and rheumatoid arthritis).
Expression host
Escherichia Coli.
Synonyms
Vascular cell adhesion protein 1, V-CAM 1, INCAM-100, CD106, VCAM1, L1CAM, MGC99561, DKFZp779G2333.
Storage Conditions
Store at 4°C if entire vial will be used within 1-2 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
References
Title: Novel Regulators of Fgf23 Expression and Mineralization in Hyp Bone Publication: Molecular Endocrinology 23.9 (2009): 1505-1518. Link: http://press.endocrine.org/doi/full/10.1210/me.2009-0085

 

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