Myeloid Cell Nuclear Differentiation Antigen Human Recombinant ( MNDA Human )

Myeloid Cell Nuclear Differentiation Antigen Human Recombinant ( MNDA Human )
$175.00

DescriptionMNDA Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 427 amino acids (1-407 a.a.) and having a molecular mass of 47.9 kDa. The MNDA is fused to a 20 amino acid His Tag at N-terminus and
Formulation
The MNDA solution contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT and 10% glycerol.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Description
MNDA Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 427 amino acids (1-407 a.a.) and having a molecular mass of 47.9 kDa. The MNDA is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.
Protein Background
MNDA plays a role as a transcriptional activator/repressor in the myeloid lineage and in the granulocyte/monocyte cell-specific response to interferon. MNDA Stimulates the DNA binding of the transcriptional repressor protein YY1. MNDA is identified only in nuclei of cells of the granulocyte-monocyte lineage. A 200-a.a region of human MNDA is remarkably related to a region in the proteins encoded by a family of interferon-inducible mouse genes, MNDA participates in blood cell-specific responses to interferons.
Expression host
Escherichia Coli.
Synonyms
PYHIN3, Myeloid cell nuclear differentiation antigen, MNDA.
Reagent Appearance
Sterile Filtered colorless solution.
Stability
MNDA although stable 4C for 4 weeks, should be stored desiccated below -18C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MVNEYKKILL LKGFELMDDY HFTSIKSLLA YDLGLTTKMQ EEYNRIKITD LMEKKFQGVA CLDKLIELAK DMPSLKNLVN NLRKEKSKVA KKIKTQEKAP VKKINQEEVG LAAPAPTARN KLTSEARGRI PVAQKRKTPN KEKTEAKRNK VSQEQSKPPG PSGASTSAAV DHPPLPQTSS STPSNTSFTP NQETQAQRQV DARRNVPQND PVTVVVLKAT APFKYESPEN GKSTMFHATV ASKTQYFHVK VFDINLKEKF VRKKVITISD YSECKGVMEI KEASSVSDFN QNFEVPNRII EIANKTPKIS QLYKQASGTM VYGLFMLQKK SVHKKNTIYE IQDNTGSMDV VGSGKWHNIK CEKGDKLRLF CLQLRTVDRK LKLVCGSHSF IKVIKAKKNK EGPMNVN.
Protein concentration
Lateral flow immunoassay.
link
Purified monoclonal IgG by protein A chromatography.

 

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